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B Braun L8002 – Sodium Chloride 0.9% Injection Solution 250mL, 24 EA/CA

B. Braun Sodium Chloride 0.9% Injection Solution 250mL, 24 EA/CA

Sodium Chloride Injections USP are sterile, nonpyrogenic, isotonic and contain no bacteriostatic or antimicrobial agents. Sodium Chloride are intravenous solutions for use in adults as well as pediatric patients as a source of water and electrolytes for hydration. 0.9% Sodium Chloride Injection USP is indicated for extracellular fluid replacement, treatment of metabolic alkalosis in the presence of fluid loss and mild sodium depletion.

Clinical Pharmacology

Sodium Chloride Injections USP are a source of electrolytes and water for hydration and they are capable of inducing diuresis depending on the clinical condition of the patient. Sodium, as the major cation of the extracellular fluid, functions primarily in the control of water distribution, fluid balance, and osmotic pressure of body fluids. Sodium is associated with chloride and bicarbonate in the regulation of the acid-base equilibrium of body fluids. Chloride, as the major extracellular anion, closely follows the metabolism of sodium, and changes in the acid-base balance of the body are reflected by changes in chloride concentration.

0.9% Sodium Chloride Injection Indications and Uses

These intravenous solutions are indicated for use in adults and pediatric patients for hydration purposes. 0.9% Sodium Chloride Injection USP is indicated for extracellular fluid replacement, treatment of metabolic alkalosis in the presence of fluid loss and mild sodium depletion. 0.9% Sodium Chloride Injection USP is also indicated for use as a priming solution in hemodialysis procedures and may be used to initiate and terminate blood transfusions without hemolyzing red blood cells. Sodium Chloride Injections USP are also indicated as pharmaceutic aids and diluents for the infusion of compatible drug additives. Refer to prescribing information accompanying additive drugs.

0.9% Sodium Chloride Injection Warnings

Administration of intravenous solutions can cause fluid or solute overload resulting in dilution of serum electrolyte concentrations, overhydration, congested states or pulmonary edema. The risk of dilutional states is inversely proportional to the electrolyte concentration. The risk of solute overload causing congested states with peripheral and pulmonary edema is directly proportional to the electrolyte concentration. Solutions containing sodium ions should be used with great care, if at all, in patients with congestive heart failure, severe renal insufficiency, and in clinical states in which there is sodium retention with edema. In patients with diminished renal function, administration of solutions containing sodium ions may result in sodium retention. Infusion of isotonic (0.9%) sodium chloride during or immediately after surgery may result in excessive sodium retention. Use the patient’s circulatory system status as a guide. Do not use 0.9% Sodium Chloride solutions when administration of sodium or chloride could be clinically detrimental.

Each 100 mL of 0.9% Sodium Chloride Injection USP contains:

  • Sodium Chloride USP 0.9 g; Water for Injection USP qs
  • pH: 5.6 (4.57.0) Calculated Osmolarity: 310 mOsmol/liter
  • pH adjusted with Hydrochloric Acid NF
  • Concentration of Electrolytes (mEq/liter): Sodium 154 Chloride 154

0.9% Sodium Chloride Injection Adverse Reactions

Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation and hypervolemia. The physician should also be alert to the possibility of adverse reactions to drug additives. Prescribing information for drug additives to be administered in this manner should be consulted. Symptoms may result from an excess or deficit of one or more of the ions present in the solution; therefore, frequent monitoring of electrolyte levels is essential. Hypernatremia may be associated with edema and exacerbation of congestive heart failure due to the retention of water, resulting in an expanded extracellular fluid volume. If infused in large amounts, chloride ions may cause a loss of bicarbonate ions, resulting in an acidifying effect. If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures, and save the remainder of the fluid for examination if deemed necessary.

B. Braun L8002 Excel IV Container Feature

Excel IV containers by B. Braun are biologically inert and not made with PVC or DEHP, therefore these containers minimize patient exposure to the toxic DEHP plasticizer compared to using PVC containers that contain DEHP.

  • Manufacturer: B. Braun L8002
  • Application: Replacement Preparation
  • Container Type: Flexible Bag
  • Dosage Form: IV Solution
  • Generic Drug Name: Sodium Chloride, Preservative Free
  • Strength: 0.9%
  • Type: Intravenous
  • Volume: 250mL
  • Excel Flexible Plastic Bag
  • PVC-Free and DEHP-Free